With the Proclamation of 1763, George III banned settlement west of the Appalachian peaks. The British government’s goal was to stave off further conflict with the Indians, the expense of which to Britain wasn’t worth the benefits to Britain. This measure was highly unpopular in America, where wealthy colonists (Washington, Mason, Morris, Franklin, Hancock, et al.) commonly held huge land claims in the West and less wealthy whites might well want to relocate.
Settlers predictably had fractious relations with both Indians and the British/colonial governments.